Dr. Sharad Gupta

Research Interest:

Protein misfolding is one of the key events in the pathogenesis of neurodegenerative disorders including Alzheimer's Disease. Sharad Gupta's lab is trying to decode the underlying mechanism of protein misfolding and finding ways to disrupt ensuing aggregation pathways. One major research focus is to identify tau aggregation inhibitors including peptides, short molecules or natural products. Along the way, his research group continues to develop methods for difficult peptide syntheses, controlled post-translational modification of proteins and new tools to detect various states of aggregation.

Background and Experience:

Associate Professor, Indian Institute of Technology Gandhinagar (Feb 2019 to present)
Assistant Professor, Indian Institute of Technology Gandhinagar (July 2012 to Jan 2019)
Postdoctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Delaware, USA, 2010 – 2012
Postdoctoral Researcher, Department of Chemistry, Temple University, USA, 2009 – 2010
PhD, University of Pittsburgh, USA, 2009
M.Sc. (Integrated), Indian Institute of Technology Kanpur, India, 2003

Selected Recent Publications:

Ralhan, K.; Guru Krishna Kumar, V.; Gupta. S., Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis.” RSC Advances, 5: 104417-104425, 2015.
Morozova, O. A.*; Gupta, S.*; Colby, D. W. “Prefibrillar Huntington oligomers isolated from HD brain potentially seed amyloid formation” FEBS letters, 589:1897-903, 2015. * Equal contribution.
Gupta, S.; Jie, S.; Colby, D. W. “Protein misfolding detected early in the pathogenesis of a transgenic mouse model of Huntington's disease using an amyloid seeding assay.” Journal of Biological Chemistry, 287: 9982-9989, 2012.
Gupta, S.; Schafmeister, C. E. “Synthesis of a Carboxylate Functionalized Bis-Amino Acid Monomer.” Journal of. Organic Chemistry, 74: 3652-3658, 2009.